BUFFALO, NY – December 2, 2022 – A new review has been published in Genes and Cancer on August 25, 2022, entitled “CDK4: a master cell cycle regulator and its role in cancer.”
The mammalian cell cycle is divided into four phases, Gap 1 (G1), Synthesis (S), Gap 2 (G2), and Mitosis (M), the order and timing of which are critical for accurate transmission of information. genetic. Therefore, a number of biochemical pathways have evolved to ensure that the initiation of a particular cell cycle event is dependent on the precise completion of another. These biochemical pathways have been called “checkpoints”.
The cell cycle is regulated in part by cyclins and their associated serine/threonine cyclin-dependent kinases, or CDKs. CDK4, in conjunction with D-type cyclins, mediates progression through the G1 phase as the cell prepares to initiate DNA synthesis. Although Cdk4-null mutant mice are viable and cell proliferation is not significantly affected in vitro due to compensatory roles played by other CDKs, this gene plays a key role in mammalian development and cancer.
In the current position paper, the researchers Stacey J. Baker, Poulikos I. Poulikakos, Hanna Y. Irie, Samir Parekh, and E.Premkumar Reddy of Icahn School of Medicine at Mount Sinai discussed the role played by CDK4 in cell cycle control, normal development and tumorigenesis, as well as the current status and usefulness of approved small molecule CDK4/6 inhibitors that are currently used as therapeutic agents against the cancer. In summary:
“CDK4/6 is a key mediator of cell cycle progression through the G1 phase, the time when a cell prepares to initiate DNA synthesis. The cell’s dependence on this protein as well as its partners in Binding to CYCLINE D and Downstream Target RB for Proliferation Highlights Why CDK4/CYCLINE D/RB Signaling Module is Often Dysregulated in Transformed Cells Approval of 3 CDK4/6 Inhibitors as Breast Cancer Treatments ER+ has paved the way for ongoing clinical studies evaluating the usefulness of these inhibitors in combination with those of other signaling pathways (such as, but not limited to, BRAF, PI3K, and MEK) in multiple tumor types that are dependent on CYCLINE D1/CDK4/RB or other cell cycle components such as p16 and p27 The success of these assays, together with the understanding of the mechanisms that drive resistance to these inhibitors, should provide an answer as to whether know if the inhi Selective CDK4/6 biters may provide therapeutic benefit in a wider range of cancers.
Read the full research paper: DOI: https://doi.org/10.18632/genesandcancer.221
Correspondence: E. Premkumar Reddy – E-mail: email@example.com
Key words: CDK4/6, cancer, cell cycle, targeted therapy, checkpoint inhibitor
About Genes and Cancer: Genes and Cancer covers all aspects of the structure and function of oncogenes, growth suppressor and apoptotic genes, their role in signal transduction and the mechanisms by which their expression and function are altered during tumor development. In addition to publishing manuscripts directly related to these areas of research, Genes and Cancer also aims to attract papers in the fields of genomics, drug development and systems biology.
To learn more about Genes and Cancervisit www.genesandcancer.com and join us on social media:
For media inquiries, please contact: firstname.lastname@example.org.
Genes and Cancer Journal Office
6666 East Quaker Street, Suite 1C
Orchard Park, NY 14127
The title of the article
CDK4: a master cell cycle regulator and its role in cancer
Publication date of articles
August 25, 2022
Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of press releases posted on EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.
#Genes #Cancer #CDK4 #master #cell #cycle #regulator #role #cancer